|
KMID : 0624620220550080363
|
|
BMB Reports
2022 Volume.55 No. 8 p.363 ~ p.369
|
|
|
Recent trends in studies of biomolecular phase separation
|
|
Kim Chan-Geun
Hwang Da-Eun
Kumar Rajeev
Chung Min
Eom Yu-Gon
Kim Hyun-Ji
Koo Da-Hyun
Choi Jeong-Mo
|
|
|
Abstract
|
|
|
|
Biomolecular phase separation has recently attracted broad interest, due to its role in the spatiotemporal compartmentalization of living cells. It governs the formation, regulation, and dissociation of biomolecular condensates, which play multiple roles in vivo, from activating specific biochemical reactions to organizing chromatin. Interestingly, biomolecular phase separation seems to be a mainly passive process, which can be explained by relatively simple physical principles and reproduced in vitro with a minimal set of components. This Mini review focuses on our current understanding of the fundamental principles of biomolecular phase separation and the recent progress in the research on this topic.
|
|
|
KEYWORD
|
|
|
Biomolecular condensates, Biomolecular phase separation, Liquid-liquid phase separation (LLPS), Phase diagram, Stickersand-spacers framework
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|